Viibryd (Vilazodone): A Novel Antidepressant for Major Depressive Disorder
Viibryd (vilazodone) is a prescription medication that belongs to a class of drugs called serotonin modulators1. It is used to treat major depressive disorder (MDD), a condition characterized by persistent and severe low mood, loss of interest, and impaired functioning 2. Viibryd is taken orally once a day, usually with food 1.
Viibryd was developed by Merck KGaA, a German pharmaceutical company, under the code name EMD-68843 3. It was first tested in clinical trials in 2001, and showed promising results for the treatment of depression 3. In 2004, Merck KGaA licensed the drug to Clinical Data, Inc., a US biotechnology company, for further development and commercialization 3. In 2011, Viibryd was approved by the US Food and Drug Administration (FDA) as the first serotonin modulator for MDD1. In 2018, Viibryd was also approved by Health Canada for the same indication 4.
Viibryd is considered both a selective serotonin reuptake inhibitor (SSRI) and a serotonin (5-HT1A) receptor partial agonist 1. Serotonin is a neurotransmitter that regulates mood, emotion, cognition, and other brain functions 5. SSRIs work by blocking the reabsorption of serotonin into nerve cells, thus increasing its availability in the brain 5. Serotonin receptor partial agonists work by stimulating certain types of serotonin receptors, which may enhance or modulate the effects of serotonin 5. The exact way that Viibryd works to treat depression is not fully understood, but it is thought to involve both mechanisms of action 1.
1. In these trials, Viibryd was compared to placebo (a dummy pill) or other antidepressants over a period of 8 to 10 weeks. The primary outcome measure was the change in the Hamilton Depression Rating Scale (HAM-D), a tool that assesses the severity of depressive symptoms. The results showed that Viibryd was significantly more effective than placebo in reducing HAM-D scores in five out of seven trials. In two trials, Viibryd also showed comparable efficacy to Lexapro (escitalopram), another SSRI antidepressant.
The recommended starting dose of Viibryd is 10 mg once daily for 7 days, followed by 20 mg once daily for 7 days, then increased to 40 mg once daily as the target dose1. The dose may be adjusted by the doctor based on the patient’s response and tolerance. The maximum dose of Viibryd is 40 mg per day. Viibryd should be taken with food to improve its absorption and reduce nausea1.
Like all medications, Viibryd may cause side effects in some people. The most common side effects of Viibryd are nausea, diarrhea, vomiting, dizziness, trouble sleeping, decreased sexual interest or ability, and dry mouth 1 . These side effects are usually mild and tend to improve over time. However, some side effects may be serious and require medical attention. These include:
Viibryd is not suitable for everyone and may be contraindicated in some people. Do not take Viibryd if you:
Before taking Viibryd, tell your doctor if you:
Also tell your doctor about all the medications, supplements, and herbal products that you are taking or plan to take, as some of them may interact with Viibryd and affect its effectiveness or safety.
Viibryd has some advantages over other antidepressants that may make it a better choice for some people. These include:
Viibryd also has some disadvantages or limitations that may make it a less suitable option for some people. These include:
Viibryd is a novel antidepressant that has been shown to be effective for the treatment of major depressive disorder in adults. It has a unique mechanism of action that involves both inhibiting the reuptake of serotonin and stimulating certain serotonin receptors in the brain. It may have some benefits over other antidepressants in terms of causing less emotional blunting and sexual dysfunction. However, it also has some drawbacks such as high cost, nausea, and drug interactions. Therefore, the decision to use Viibryd should be based on a careful evaluation of the individual patient’s needs, preferences, and medical history, as well as a discussion with their doctor about the potential risks and benefits of the medication.
Viibryd is a new antidepressant that has been shown to be effective in treating both depression and anxiety. We'll learn about the composition of Viibryd and how it works to treat depression and anxiety. We'll also learn about the potential side effects of Viibryd, and discuss the professional knowledge you need to take Viibryd.